In a medium bowl, combine the ground turkey, garlic powder, onion powder, sea salt, and black pepper.
Gently mix the ingredients by hand until just combined, being careful not to overwork the meat to ensure a tender patty.
Form the mixture into one large, thick patty, pressing a slight indentation into the center with your thumb to prevent bulging during cooking.
Heat the olive oil in a cast-iron skillet or non-stick pan over medium-high heat until shimmering.
Place the patty in the skillet and sear for 5 to 6 minutes on the first side until a golden-brown crust forms.
Flip the burger and cook for another 5 minutes, or until the internal temperature reaches 165°F.
While the burger rests for 2 minutes, prepare your lettuce wrap by laying out the butter lettuce leaf on a clean plate.
Place the turkey patty onto the lettuce, then top with the Dijon mustard, tomato slice, red onion, and the creamy avocado slices.