Preheat your oven to 425°F and line a baking sheet with parchment paper to prevent sticking.
In a shallow dish, pour the buttermilk and season with a pinch of salt and pepper. Place the chicken breast in the buttermilk, ensuring it is fully submerged, and let it marinate for at least 30 minutes (or up to overnight in the refrigerator for deeper flavor).
In another dish, combine the panko breadcrumbs, paprika, and garlic powder.
Remove the chicken from the buttermilk marinade, allowing the excess to drip off. Dredge the chicken in the breadcrumb mixture, pressing gently so the coating adheres well.
Place the coated chicken on the prepared baking sheet. For extra crispiness, lightly spray the top with cooking spray.
Bake the chicken in the preheated oven for 20-25 minutes, or until the chicken reaches an internal temperature of 165°F and the coating is golden brown.
Remove from the oven, let it rest for a few minutes, then serve and enjoy your crispy, flavorful buttermilk chicken.