Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper.
In a small bowl, whisk the egg white. In a separate shallow dish, place the panko bread crumbs.
Pat the chicken breast dry and lightly season with a pinch of salt and pepper if desired.
Dip each chicken piece into the egg white, ensuring an even coat, then dredge in the panko bread crumbs, pressing gently to adhere.
Arrange the breaded chicken on the prepared baking sheet.
In a small saucepan, combine honey, soy sauce, rice vinegar, minced garlic, red bell pepper slices, and pineapple chunks. Bring to a simmer over medium heat, stirring occasionally until the sauce slightly thickens (about 3-4 minutes).
Brush half of the sauce evenly over the chicken.
Bake the chicken in the preheated oven for 18-20 minutes or until the chicken reaches an internal temperature of 165°F (74°C) and the coating is crispy.
Remove the chicken from the oven and drizzle with the remaining sauce.
Serve immediately and enjoy your crispy baked sweet and sour chicken.