Preheat your oven to 425°F (220°C) and prepare a baking sheet by lining it with parchment paper or lightly spraying with olive oil spray.
In a bowl, whisk together the low-fat buttermilk, garlic powder, onion powder, a pinch of salt, and black pepper.
Place the chicken breast in the bowl, ensuring it is fully submerged. Cover and refrigerate for at least 30 minutes to allow the flavors to penetrate.
In a separate shallow dish, combine the whole wheat flour with an additional pinch of salt and pepper.
Remove the chicken from the buttermilk marinade, allowing the excess to drip off. Dredge the chicken in the flour mixture, coating it evenly on all sides.
Place the coated chicken on the prepared baking sheet. Lightly spray the top with olive oil spray to aid in creating a crispy crust.
Bake in the preheated oven for 20-25 minutes or until the chicken is cooked through and the coating is lightly golden and crispy.
Remove from the oven, let it rest for a few minutes, and serve immediately. Enjoy your crispy, high-protein meal!