Slice the chicken breast into thick strips to ensure even cooking and maximum surface area for the crust.
Place the chicken in a small bowl with the buttermilk, tossing to coat thoroughly, and let it marinate for at least 15 minutes.
In a separate shallow dish, whisk together the whole wheat flour, garlic powder, onion powder, paprika, sea salt, and black pepper.
Remove each chicken strip from the buttermilk, allowing excess liquid to drip off, then dredge firmly in the seasoned flour mixture until fully coated.
Lightly brush or spray the breaded chicken strips with avocado oil and place them in the air fryer basket.
Air fry at 375°F for 12-15 minutes, flipping halfway through, until the exterior is golden brown and the chicken is cooked through.
While the chicken finishes, warm the whole wheat biscuit in the oven or air fryer until the center is soft and the exterior is slightly crisp.
Serve the crispy chicken immediately alongside the warm biscuit for a clean-eating version of classic comfort food.