Preheat your oven to 400°F and line a rimmed baking sheet with parchment paper.
Trim the woody ends off the asparagus spears and place them on the prepared baking sheet.
Drizzle the asparagus with half of the olive oil and season with a pinch of sea salt and black pepper, tossing to coat evenly.
Roast the asparagus for 12 to 15 minutes until tender and slightly charred at the tips.
While the vegetables roast, pat the salmon fillet completely dry with a paper towel to ensure maximum crispiness.
Season the salmon on all sides with the remaining sea salt, black pepper, and garlic powder.
Heat the remaining olive oil in a stainless steel or cast iron skillet over medium-high heat until the oil is shimmering.
Place the salmon skin-side down in the hot skillet and press firmly with a spatula for 10 seconds to prevent curling.
Cook undisturbed for 4 to 5 minutes until the skin is golden and crispy, then carefully flip and cook for another 2 to 3 minutes.
Remove from heat and serve the salmon alongside the roasted asparagus with a fresh lemon wedge for squeezing.