Bring a large pot of salted water to a boil and cook the whole wheat penne until al dente, reserving 1/4 cup of the pasta water before draining.
Heat the olive oil in a large skillet over medium-high heat and add the cubed chicken breast, seasoning with half of the sea salt and black pepper.
Sauté the chicken for 5-6 minutes until golden brown and cooked through, then remove from the pan and set aside.
In the same skillet, add the sliced cremini mushrooms and sauté for 4 minutes until they release their moisture and turn a deep golden brown.
Add the minced garlic to the mushrooms and cook for 30 seconds until fragrant, then return the chicken to the pan.
Reduce heat to low, then stir in the Greek yogurt, parmesan cheese, and reserved pasta water, whisking gently to create a smooth, creamy sauce.
Fold in the cooked pasta and drizzle with truffle oil, tossing everything until well coated and heated through.
Garnish with chopped fresh parsley and the remaining salt and pepper before serving immediately.