Preheat your oven to 400°F and line a baking sheet with parchment paper.
In a small skillet over medium heat, cook the turkey sausage until browned and fully cooked through, then set aside.
In a medium mixing bowl, stir together the Greek yogurt and flour until a shaggy dough forms.
Turn the dough onto a lightly floured surface and knead for 1-2 minutes until smooth.
Roll the dough out into a thin circle, approximately 8 inches in diameter.
Spread the tomato sauce over one half of the dough circle, leaving a half-inch border at the edge.
Layer the cooked sausage, turkey pepperoni, and mozzarella cheese over the sauce.
Sprinkle the garlic powder, dried oregano, sea salt, and black pepper over the filling.
Fold the empty half of the dough over the filling and use a fork to crimp the edges tightly to seal.
Bake for 15-18 minutes, or until the crust is golden brown and crispy to the touch.