Preheat your oven to 400°F and line a large rimmed baking sheet with parchment paper.
Spread the broccoli florets, sliced red bell pepper, and shelled edamame on the baking sheet, then drizzle with the tamari and toss to coat.
Roast the vegetables for 18-20 minutes until they are tender and show light charred edges.
While the vegetables roast, press the tofu with a heavy object for 10 minutes to remove excess moisture, then cut into 1-inch cubes.
In a shallow bowl, whisk together the nutritional yeast, garlic powder, onion powder, sea salt, and black pepper.
Toss the tofu cubes in the nutritional yeast mixture until every side is thoroughly coated.
Heat the toasted sesame oil in a large non-stick skillet over medium-high heat.
Add the tofu to the skillet and sear for 3-4 minutes per side until a golden, crispy crust forms on all sides.
Divide the roasted vegetable medley between plates and top with the crispy pan-seared tofu.