Preheat your oven to 400°F (200°C) and line a large baking sheet with parchment paper for easy cleanup.
Trim the tough, woody ends off the asparagus spears and finely mince the garlic clove.
In a small mixing bowl, whisk together the honey, Dijon mustard, minced garlic, and lemon juice until the glaze is well combined.
Arrange the salmon fillet and the trimmed asparagus spears in a single layer on the prepared baking sheet.
Drizzle the olive oil over the asparagus and toss lightly to coat, then season both the salmon and asparagus with the sea salt and black pepper.
Brush the honey-Dijon glaze generously over the top and sides of the salmon fillet to ensure maximum flavor.
Place the baking sheet in the center of the oven and roast for 12 to 15 minutes, or until the salmon is opaque and flakes easily with a fork.
Remove from the oven and serve immediately, drizzling any remaining pan juices over the salmon for extra moisture.