Press the extra firm tofu for 15 minutes using a tofu press or heavy skillet to remove excess moisture, then cut into 1-inch cubes.
Heat a large non-stick skillet or wok over medium-high heat and add the toasted sesame oil.
Add the tofu cubes to the hot skillet and sear until golden brown and crispy on all sides, approximately 8 to 10 minutes.
Add the broccoli florets, sliced red bell pepper, and shelled edamame to the skillet, sautéing for 5 minutes until the vegetables are tender-crisp.
In a small bowl, whisk together the tamari, rice vinegar, grated fresh ginger, minced garlic, sea salt, black pepper, and red pepper flakes.
Pour the sauce mixture over the tofu and vegetables, tossing constantly for 2 minutes to ensure everything is glazed and heated through.
Remove from heat and garnish with sesame seeds before serving immediately.