Preheat your oven to 300°F (150°C).
Combine the smoked paprika, garlic powder, onion powder, sea salt, and black pepper in a small bowl.
Rub the spice mixture evenly over all sides of the beef brisket.
Heat avocado oil in a heavy, oven-safe skillet or Dutch oven over medium-high heat and sear the brisket until browned on all sides.
Pour the beef bone broth into the pan, cover tightly with a lid or foil, and transfer to the oven.
Roast for 3 to 4 hours, or until the brisket is tender and easily shreds with a fork.
While the meat rests, melt ghee in a separate pan over medium-low heat and add the thinly sliced yellow onion.
Sauté the onion slowly for 20-25 minutes until deeply golden and caramelized.
Slice the brisket against the grain and serve topped with the warm caramelized onions.