Preheat your oven to 400°F and line a large rimmed baking sheet with parchment paper.
Press the tofu for at least 15 minutes using a tofu press or heavy skillet to remove excess moisture, then cut into 1-inch cubes.
Chop the broccoli florets and the red bell pepper into uniform, bite-sized pieces.
In a large mixing bowl, whisk together the tamari, toasted sesame oil, garlic powder, ginger powder, sea salt, and black pepper.
Add the tofu cubes, broccoli, and bell peppers to the bowl, tossing gently until every piece is thoroughly coated in the glaze.
Spread the mixture in a single layer on the prepared baking sheet and sprinkle the sesame seeds evenly over the top.
Roast for 25 to 30 minutes, flipping the tofu and vegetables halfway through, until the tofu is golden brown and the vegetables are tender-crisp.