Preheat your oven to 425°F and line a large rimmed baking sheet with parchment paper.
Cut the chicken breast into 1-inch bite-sized cubes and chop the cauliflower into small, uniform florets.
In a large mixing bowl, combine the chicken and cauliflower with olive oil, garlic powder, onion powder, sea salt, and black pepper, tossing until every piece is evenly coated.
Spread the mixture in a single layer on the prepared baking sheet, ensuring there is space between pieces for maximum crispiness.
Roast for 20-22 minutes, flipping halfway through, until the chicken is cooked through and the cauliflower edges are golden brown.
While roasting, whisk together the Greek yogurt and finely chopped chives in a small bowl to create the dip.
Remove the tray from the oven and immediately transfer the chicken and cauliflower to a clean bowl; toss with the buffalo hot sauce until fully glazed.
Serve the warm buffalo bites immediately with the chilled yogurt dip on the side.