Preheat your oven to 400°F and line a large rimmed baking sheet with parchment paper for easy cleanup.
Wrap the tofu block in a clean kitchen towel and place a heavy skillet on top to press for 15 minutes, then slice into 1-inch cubes.
In a large mixing bowl, combine the tofu cubes, broccoli florets, sliced red bell pepper, and shelled edamame.
Drizzle with toasted sesame oil and low-sodium tamari, then sprinkle with garlic powder, ground ginger, sea salt, and black pepper, tossing until evenly coated.
Arrange the mixture in a single layer on the baking sheet and roast for 25-30 minutes, flipping halfway through, until the tofu is golden brown.
Garnish with sesame seeds and serve immediately while the vegetables are tender and the tofu is crisp.