In a small bowl, whisk together the Greek yogurt, yellow mustard, pickle juice, and smoked paprika until smooth to create the clean secret sauce.
Finely shred the romaine lettuce, dice the pickles, finely mince the red onion, and halve the cherry tomatoes.
Heat the olive oil in a cast-iron skillet over medium-high heat until shimmering.
Add the ground beef to the skillet, seasoning with sea salt, black pepper, garlic powder, and onion powder.
Cook the beef undisturbed for 3-4 minutes to develop a deep brown crust, then break it apart and continue sautéing until fully cooked and crispy.
Place the shredded romaine in a large bowl as the base.
Top the lettuce with the crispy beef, pickles, red onion, and cherry tomatoes.
Drizzle the prepared secret sauce over the bowl and garnish with toasted sesame seeds before serving.