Preheat your oven to 425°F and line a large rimmed baking sheet with parchment paper for easy cleanup.
Cut the chicken breast into 1-inch bite-sized cubes and chop the cauliflower into similar-sized florets.
In a large mixing bowl, combine the chicken and cauliflower with olive oil, garlic powder, onion powder, sea salt, and black pepper, tossing until every piece is evenly coated.
Spread the mixture in a single layer on the prepared baking sheet, ensuring there is space between the pieces so they roast rather than steam.
Roast for 20 to 25 minutes, flipping the pieces halfway through, until the chicken is cooked through and the cauliflower edges are charred and tender.
While the tray is in the oven, whisk together the Greek yogurt and finely chopped fresh chives in a small bowl to create a high-protein cooling dip.
Remove the tray from the oven and immediately transfer the roasted chicken and cauliflower to a clean bowl; toss with the buffalo sauce until well glazed.
Serve the warm buffalo bites immediately with the chilled chive yogurt dip on the side.