Preheat your oven to 425°F and line a large rimmed baking sheet with parchment paper for easy cleanup.
Cut the chicken breast into 1-inch cubes and break the cauliflower into small, uniform bite-sized florets.
In a small bowl, whisk together the melted ghee, buffalo hot sauce, garlic powder, onion powder, sea salt, and black pepper until well combined.
Place the chicken and cauliflower in a large mixing bowl, pour over the buffalo mixture, and toss thoroughly to ensure every piece is evenly coated.
Spread the mixture in a single layer on the prepared baking sheet, ensuring there is space between the pieces to allow for maximum crispiness.
Roast in the oven for 20 to 25 minutes, flipping halfway through, until the chicken is cooked through and the cauliflower edges are golden and charred.
Remove from the oven and serve immediately with a side of Greek yogurt for dipping and a garnish of fresh chopped chives.