In a medium bowl, combine the ground bison, egg, almond flour, sea salt, black pepper, garlic powder, and onion powder.
Gently mix the ingredients with your hands until just combined, being careful not to overwork the meat, and form into 6 even meatballs.
Heat the extra virgin olive oil in a large skillet over medium-high heat.
Place the meatballs in the skillet and sear for 2-3 minutes per side until a golden-brown crust forms on the exterior.
Pour the tomato puree and smoked paprika into the skillet, stirring gently around the meatballs to incorporate the flavors.
Reduce the heat to low, cover the skillet with a lid, and simmer for 8-10 minutes until the meatballs are cooked through and the sauce has thickened.
While the meatballs simmer, lightly sauté the zucchini noodles in a separate pan for 2 minutes until just tender but still bright green.
Serve the bison meatballs and smoky sauce over the bed of zucchini noodles, garnished with freshly chopped parsley.