Preheat your oven to 400°F and line a large rimmed baking sheet with parchment paper.
Cut the tempeh into 0.5-inch cubes and place them in a large mixing bowl along with the broccoli florets and sliced red bell pepper.
In a small bowl, whisk together the tamari, toasted sesame oil, rice vinegar, garlic powder, and ground ginger until well combined.
Drizzle half of the sesame sauce over the tempeh and vegetables, tossing thoroughly to ensure everything is evenly coated.
Spread the mixture in a single layer on the prepared baking sheet and roast for 20 minutes, tossing halfway through.
Add the shelled edamame to the baking sheet and roast for an additional 5 minutes until the tempeh is golden and the vegetables are tender.
Remove from the oven, drizzle with the remaining sauce, and finish with a sprinkle of sesame seeds, sea salt, and black pepper.