Preheat your oven to 425°F and line a large rimmed baking sheet with parchment paper to prevent sticking.
Cut the chicken breast into bite-sized cubes and break the cauliflower into small, uniform florets.
In a large mixing bowl, combine the chicken and cauliflower with melted ghee, garlic powder, onion powder, sea salt, and black pepper, tossing until every piece is evenly coated.
Spread the mixture onto the prepared baking sheet in a single layer, making sure not to crowd the pan so the ingredients roast rather than steam.
Roast for 20 to 25 minutes, flipping the pieces halfway through, until the chicken is cooked through and the cauliflower has developed dark, crispy edges.
While the tray is in the oven, whisk together the Greek yogurt, minced fresh chives, and lemon juice in a small bowl to create a creamy ranch-style dip.
Remove the tray from the oven and immediately transfer the hot chicken and cauliflower to a clean bowl, tossing them with the buffalo hot sauce until fully glazed.
Serve the buffalo bites immediately while hot, with the cooling yogurt dip on the side.