Pat the salmon fillet completely dry with a paper towel to ensure a crispy sear, then season both sides evenly with sea salt, black pepper, and dried oregano.
Melt the ghee in a large non-stick skillet over medium-high heat until it shimmeringly coats the bottom of the pan.
Place the salmon in the skillet, skin-side down, and press gently with a spatula; sear for 4 to 5 minutes until the skin is golden and releases easily.
Flip the fillet and toss in the trimmed asparagus spears, halved cherry tomatoes, and minced garlic into the open spaces of the pan.
Sauté the vegetables for 3 to 4 minutes while the salmon finishes cooking through, ensuring the garlic becomes fragrant but not burnt.
Remove from heat, squeeze fresh lemon juice over the entire dish to brighten the flavors, and serve immediately while the salmon is flaky and moist.