Preheat your oven to 425°F and line a baking sheet with parchment paper for easy cleanup.
In a small non-stick skillet, brown the lean ground turkey over medium heat until cooked through.
In a medium bowl, stir together the Greek yogurt and self-rising flour until a shaggy dough ball forms.
Knead the dough briefly on a lightly floured surface until smooth, then roll it into a thin 8-inch circle.
Slice one quarter of the mozzarella into thin strips and place them along the perimeter of the dough circle.
Fold the dough edges over the cheese strips, pressing firmly to create a sealed, stuffed outer crust.
Spread the tomato puree evenly over the center and season with oregano, garlic powder, salt, and pepper.
Layer on the cooked turkey, Canadian bacon, and turkey pepperoni, then finish with the remaining mozzarella.
Bake for 12 to 15 minutes until the crust is golden and the cheese is beautifully melted and bubbly.