Preheat your oven to 400°F (200°C) and line a large baking sheet with parchment paper.
Chop the broccoli, red bell pepper, and zucchini into uniform bite-sized pieces for even cooking.
Place the vegetables on the baking sheet and toss with 1 tablespoon of olive oil, 0.5 teaspoon of garlic powder, sea salt, and black pepper.
Roast the vegetables for 18 to 20 minutes until they are tender and show slight caramelized edges.
While vegetables roast, pat the tilapia fillets dry with a paper towel and season both sides with the remaining garlic powder, onion powder, smoked paprika, and lemon zest.
Heat the remaining 1 teaspoon of olive oil in a large non-stick skillet over medium-high heat.
Place the tilapia in the skillet and sear for 3 to 4 minutes per side until the fish is opaque and flakes easily with a fork.
During the last 30 seconds of cooking, add the minced garlic and a squeeze of fresh lemon juice to the pan to infuse the fish with flavor.
Serve the zesty tilapia immediately alongside the roasted vegetable medley.