Heat a non-stick skillet over medium-high heat and add the ground beef, breaking it apart with a spatula.
Season the beef with sea salt and black pepper, cooking until browned and fully cooked through.
While the beef cooks, whisk together the Greek yogurt, mustard, ketchup, garlic powder, onion powder, and smoked paprika in a small bowl to create the special sauce.
Finely shred the romaine lettuce and dice the red onion, pickles, and cherry tomatoes.
Assemble the bowl by placing the shredded lettuce at the base, followed by the cooked ground beef.
Top the beef with the diced onions, pickles, and cherry tomatoes.
Drizzle the creamy special sauce over the entire bowl and garnish with sesame seeds before serving.