In a small skillet, brown the ground turkey over medium heat until fully cooked and no longer pink.
In a medium mixing bowl, combine the cooked turkey, cooked macaroni, shredded cheddar, Greek yogurt, sea salt, garlic powder, onion powder, and smoked paprika.
Stir the mixture vigorously until the cheese and yogurt form a thick, cohesive sauce around the pasta and meat.
Place the bowl in the refrigerator for at least 30 minutes to allow the mixture to firm up for easier shaping.
Once chilled, scoop the mixture and roll into small, even-sized balls.
Whisk the egg in one shallow bowl and place the panko breadcrumbs in a second shallow bowl.
Dredge each ball first in the egg wash, then roll in the panko until completely and evenly coated.
Heat the avocado oil in a non-stick skillet over medium-high heat.
Carefully place the balls in the hot oil and fry for 2-3 minutes per side, turning gently, until the exterior is golden and crunchy.
Transfer the bites to a paper towel-lined plate to drain briefly before serving.