Preheat your oven to 400°F and line a large rimmed baking sheet with parchment paper for easy cleanup.
Trim the tough, woody ends off the asparagus spears and spread them out in a single layer on one side of the prepared baking sheet.
Place the salmon fillet on the other side of the baking sheet, ensuring there is a little space between the fish and the vegetables.
In a small bowl, whisk together the extra virgin olive oil, lemon juice, dried oregano, garlic powder, sea salt, and black pepper.
Brush half of the lemon-herb mixture over the top of the salmon fillet and drizzle the remaining half over the asparagus, tossing the spears to coat.
Slide the pan into the oven and roast for 12 to 15 minutes, or until the salmon is opaque and flakes easily with a fork and the asparagus is tender-crisp.
Remove from the oven, garnish the entire dish with fresh chopped parsley, and serve while hot.