In a small mixing bowl, whisk together the non-fat Greek yogurt, yellow mustard, sugar-free pickle relish, smoked paprika, and half of the garlic powder until the sauce is smooth and well combined.
Heat the extra virgin olive oil in a large skillet over medium-high heat.
Add the ground beef to the skillet, seasoning it with the sea salt, black pepper, onion powder, and the remaining garlic powder.
Cook the beef, breaking it apart with a spatula, until it is thoroughly browned and slightly crispy on the edges, about 7 to 9 minutes.
While the beef cooks, finely shred the iceberg lettuce and dice the red onion and dill pickles into small pieces.
In a large serving bowl, create a base with the shredded iceberg lettuce.
Top the lettuce with the warm cooked ground beef, diced red onions, and pickles.
Drizzle the prepared Greek yogurt special sauce generously over the bowl and finish by sprinkling with sesame seeds.