Preheat your oven to 400°F and line a large rimmed baking sheet with parchment paper.
Press the tofu for 15 minutes using a tofu press or heavy skillet to remove excess moisture, then slice into uniform 1-inch cubes.
Place the broccoli florets and bell pepper strips on the baking sheet, drizzle with half of the sesame oil, and sprinkle with the sea salt and black pepper.
Roast the vegetables for 20 minutes until they are tender and show slight caramelization at the edges.
In a medium mixing bowl, whisk together the nutritional yeast, garlic powder, and onion powder, then toss the tofu cubes in the mixture until evenly coated.
Heat the remaining sesame oil in a large non-stick skillet over medium-high heat.
Add the coated tofu cubes to the skillet and sear for 3 to 4 minutes per side until each face is golden brown and crispy.
Stir in the shelled edamame and tamari, cooking for an additional 2 minutes until the edamame is bright green and heated through.
Transfer the roasted vegetables from the oven into the skillet, toss gently to combine all ingredients, and serve immediately.