Preheat your oven to 400°F (200°C) and line a large rimmed baking sheet with parchment paper for easy cleanup.
Trim the tough, woody ends off the asparagus spears and place them on one side of the prepared baking sheet.
Place the salmon fillet on the other side of the baking sheet, ensuring there is space between the fish and the vegetables.
In a small glass bowl, whisk together the extra virgin olive oil, fresh lemon juice, minced garlic, dried oregano, sea salt, and black pepper.
Drizzle the lemon-herb mixture evenly over both the salmon and the asparagus, using a pastry brush to ensure the salmon is fully coated.
Slide the baking sheet into the oven and bake for 12 to 15 minutes, or until the salmon flakes easily with a fork and the asparagus is bright green and tender-crisp.
Serve immediately, optionally garnished with fresh lemon slices for an extra pop of brightness.