Preheat oven to 400°F and line a large baking sheet with parchment paper.
Press the tofu for 15 minutes to remove excess moisture, then cut into 1-inch cubes.
Chop the eggplant, zucchini, and summer squash into uniform bite-sized pieces.
In a large bowl, whisk together the olive oil, tamari, garlic powder, onion powder, salt, and pepper.
Add the tofu and vegetables to the bowl, tossing gently until every piece is evenly coated.
Sprinkle the nutritional yeast over the mixture and toss once more to create a light crust.
Spread the medley in a single layer on the prepared baking sheet, ensuring no pieces are overlapping.
Roast for 25-30 minutes, flipping halfway through, until the tofu is crispy and the vegetables are tender.