Preheat your oven to 400°F and line a small baking sheet with parchment paper.
In a large skillet over medium-high heat, brown the ground beef until fully cooked, breaking it into small crumbles with a spatula.
Add the diced bell peppers and red onions to the skillet with the beef, sautéing for 3-4 minutes until the vegetables are tender-crisp.
Stir in the chili powder, ground cumin, garlic powder, sea salt, and black pepper, ensuring the mixture is evenly seasoned.
Arrange the corn tortilla chips in a single layer on the prepared baking sheet.
Spoon the seasoned beef and vegetable mixture evenly over the chips and sprinkle with the shredded sharp cheddar cheese.
Bake for 5-7 minutes, or until the cheese is bubbly and the chips are lightly toasted.
Remove from the oven and top with a dollop of Greek yogurt, sliced avocado, pickled jalapeños, and fresh cilantro before serving immediately.