In a medium mixing bowl, combine the ground turkey with sea salt, black pepper, garlic powder, and onion powder until just incorporated.
Gently form the turkey mixture into a single thick patty, being careful not to overwork the meat to keep it tender.
Heat the avocado oil in a cast-iron skillet or non-stick pan over medium-high heat until shimmering.
Place the patty in the skillet and sear for 5 to 6 minutes on the first side until a golden-brown crust forms.
Flip the burger and cook for another 5 minutes, or until the internal temperature reaches a safe 165°F.
While the burger rests for two minutes, lay the butter lettuce leaves flat on a plate to serve as your bun.
Spread the Dijon mustard onto the center of the lettuce leaves and top with the tomato slices.
Place the cooked turkey patty over the tomatoes, then layer on the sliced avocado and a generous mound of clover sprouts.
Fold the lettuce leaves over the top to secure the burger and enjoy immediately while warm.