Preheat your oven to 300°F.
In a small bowl, combine the smoked paprika, garlic powder, onion powder, sea salt, and black pepper to create a dry rub.
Rub the spice mixture evenly over all sides of the beef brisket.
Heat a large oven-safe skillet over medium-high heat and sear the brisket for 3-4 minutes per side until a dark crust forms.
Add the water to the skillet, cover tightly with a lid or foil, and transfer to the oven to roast for 3 hours or until fork-tender.
While the meat rests, toss the Brussels sprouts with olive oil and roast at 400°F for 20 minutes on a separate tray.
Whisk together the tomato paste, apple cider vinegar, and maple syrup to create the BBQ glaze.
Brush the glaze over the cooked brisket and broil for 2-3 minutes until the sauce is tacky and caramelized.
Slice the brisket against the grain and serve alongside the roasted Brussels sprouts.