Heat the avocado oil in a large cast-iron skillet over medium-high heat until shimmering.
Add the cubed sweet potatoes to the skillet and cook for 8-10 minutes, stirring occasionally, until they are tender and golden brown.
Push the potatoes to the outer edges of the pan and add the ground bison to the center, breaking it apart with a wooden spoon.
Cook the bison until browned and no longer pink, approximately 5-6 minutes.
Stir in the diced red onion and red bell peppers, sautéing for another 3-4 minutes until the vegetables have softened.
Sprinkle the sea salt, black pepper, smoked paprika, and garlic powder over the mixture and stir thoroughly to combine all flavors.
Add the chopped kale to the skillet and toss for 1-2 minutes until the leaves are just wilted and bright green.
Remove from heat and serve immediately.