Preheat your oven to 400°F and line a baking sheet with parchment paper.
Toss the broccoli, carrots, and cauliflower with half of the olive oil, sea salt, and black pepper on the prepared sheet.
Roast the vegetables for 15-20 minutes until they are tender and show slight caramelized edges.
While vegetables roast, bring a pot of water to a boil and cook the pasta according to package directions until al dente, then drain.
Heat the remaining olive oil in a large skillet over medium-high heat and add the ground turkey and garlic powder.
Cook the turkey, breaking it into crumbles with a spatula, until it is browned and cooked through.
In a small bowl, whisk together the red wine vinegar, Dijon mustard, and dried oregano to create the glaze.
Add the cooked pasta and roasted vegetables into the skillet with the turkey.
Pour the glaze over the mixture and toss everything together for 1-2 minutes until heated through and well coated.