In a small bowl, combine the smoked paprika, garlic powder, onion powder, dried thyme, dried oregano, cayenne pepper, sea salt, and black pepper.
Pat the salmon fillet dry with a paper towel and rub the spice mixture evenly over both sides of the fish.
Heat the ghee in a medium cast-iron skillet over medium-high heat until shimmering.
Place the salmon in the skillet flesh-side down and sear for 3 to 4 minutes until a dark, flavorful crust forms.
Flip the salmon to the skin side and add the minced garlic and asparagus spears to the pan.
Cook for another 3 to 4 minutes, tossing the asparagus in the pan juices until the salmon is cooked through and the asparagus is crisp-tender.
Drizzle the lemon juice over the salmon and asparagus before serving.