Preheat your oven to 400°F (200°C) and line a large sheet pan with parchment paper to ensure easy cleanup and prevent sticking.
Wash the asparagus and trim away the tough, woody ends, then spread the spears out across one half of the prepared sheet pan.
Place the salmon fillet on the remaining half of the sheet pan, leaving a bit of space between the fish and the vegetables for even heat circulation.
In a small glass bowl, whisk together the extra virgin olive oil, fresh lemon juice, lemon zest, dried oregano, garlic powder, sea salt, and black pepper.
Drizzle the lemon-herb mixture over both the salmon and the asparagus, using a pastry brush or your fingers to ensure every inch is well-coated.
Slide the pan into the center of the oven and roast for 12 to 15 minutes, depending on the thickness of the fillet, until the salmon flakes easily with a fork.
Remove from the oven once the asparagus is tender-crisp and serve immediately for a fresh, high-protein dinner.