Preheat the oven to 400°F and line a large baking sheet with parchment paper.
Wrap the tofu in a clean kitchen towel and place a heavy object on top for 15 minutes to press out excess moisture.
Slice the pressed tofu into 1-inch cubes and place them in a large mixing bowl.
Add the broccoli florets, sliced red bell pepper, and shelled edamame to the bowl with the tofu.
In a small jar, whisk together the tamari, toasted sesame oil, minced ginger, minced garlic, rice vinegar, red pepper flakes, sea salt, and black pepper.
Pour the sauce over the tofu and vegetables, tossing gently to ensure everything is well-coated.
Spread the mixture in a single layer on the prepared baking sheet, ensuring the pieces are not overcrowded.
Bake for 25 to 30 minutes, tossing the ingredients halfway through, until the tofu is golden and the vegetables are tender.