Pat the salmon fillet dry with paper towels to ensure a crisp sear.
In a small bowl, combine the smoked paprika, garlic powder, onion powder, dried oregano, cayenne pepper, sea salt, and black pepper.
Rub the spice mixture generously over both sides of the salmon fillet.
Heat the avocado oil in a cast-iron skillet over medium-high heat until shimmering.
Place the salmon in the skillet and sear for 4 minutes until a dark, flavorful crust forms.
Carefully flip the fillet and cook for another 3-4 minutes until the internal temperature reaches 145°F.
While the salmon is cooking, dice the avocado, quarter the cherry tomatoes, and finely mince the red onion.
In a small bowl, toss the avocado, tomatoes, and onion with fresh cilantro and lime juice.
Top the blackened salmon with the fresh avocado salsa and serve immediately.