Heat a large non-stick skillet over medium-high heat.
Add the ground beef, garlic powder, onion powder, sea salt, and black pepper to the skillet.
Cook the beef, breaking it into small crumbles with a spatula, until fully browned and no longer pink.
While the beef cooks, finely chop the white onion and slice the dill pickles into rounds.
In a small bowl, whisk together the Greek yogurt, yellow mustard, unsweetened ketchup, pickle juice, and smoked paprika until smooth.
Place the shredded romaine lettuce into a large serving bowl.
Top the lettuce with the cooked ground beef, chopped onions, and sliced pickles.
Drizzle the creamy special sauce over the bowl and garnish with sesame seeds before serving.