Preheat oven to 400°F and line a baking sheet with parchment paper.
Press the tofu for 15 minutes to remove excess moisture, then cut into 1-inch cubes.
Toss broccoli, bell peppers, and edamame with half the sesame oil, sea salt, and black pepper on the baking sheet.
Roast the vegetables for 18-20 minutes until tender and slightly charred.
In a bowl, toss the tofu cubes with nutritional yeast, garlic powder, and onion powder until well coated.
Heat the remaining sesame oil in a large skillet over medium-high heat.
Add tofu to the skillet and sear for 3-4 minutes per side until a crispy golden crust forms.
Pour the tamari over the tofu in the skillet, tossing for 30 seconds to glaze.
Plate the roasted vegetables and top with the savory seared tofu.