Preheat your oven to 400°F and line a large baking sheet with parchment paper.
Wrap the extra firm tofu in a clean kitchen towel and place a heavy skillet on top for 15 minutes to press out excess moisture.
Halve the radishes and mushrooms, then place them on the baking sheet with the cherry tomatoes.
Drizzle the vegetables with half of the olive oil and sprinkle with half of the sea salt and black pepper, tossing to coat evenly.
Roast the vegetables in the oven for 20 minutes until the radishes are tender and the tomatoes have just begun to burst.
Cut the pressed tofu into 1-inch cubes and toss in a bowl with nutritional yeast, garlic powder, and the remaining salt and pepper.
Heat the remaining olive oil in a large non-stick skillet over medium-high heat.
Add the tofu cubes to the skillet and sear for 8-10 minutes, turning occasionally until a savory golden crust forms on all sides.
Pour the tamari over the tofu in the last minute of cooking, tossing quickly to glaze the cubes.
Remove the roasted vegetables from the oven and divide them into bowls, topping with the pan-seared tofu cubes.