Preheat your oven to 400°F (200°C) and line a large rimmed baking sheet with parchment paper for easy cleanup.
Wash the asparagus and trim off the tough, woody ends before placing the spears on one side of the prepared baking sheet.
Pat the salmon fillet dry with a paper towel and place it on the other side of the baking sheet.
In a small glass bowl, whisk together the extra virgin olive oil, fresh lemon juice, lemon zest, minced garlic, and dried oregano.
Drizzle the lemon-herb mixture evenly over both the salmon fillet and the asparagus spears.
Sprinkle the sea salt and black pepper over the entire tray to season.
Bake for 12 to 15 minutes, depending on the thickness of the salmon, until the fish flakes easily with a fork and the asparagus is perfectly crisp-tender.
Transfer to a plate and serve immediately, optionally garnished with fresh parsley or an extra squeeze of lemon.