Drain and press the firm tofu for at least 15 minutes to remove excess moisture, then cut into 1-inch cubes.
In a small bowl, whisk together the tamari, honey, toasted sesame oil, grated ginger, minced garlic, and red pepper flakes to create the stir-fry sauce.
Heat the avocado oil in a large non-stick skillet or wok over medium-high heat until shimmering.
Add the tofu cubes to the skillet in a single layer and sear for 3-4 minutes per side until they develop a golden-brown, crispy exterior.
Toss in the broccoli florets, sliced red bell pepper, and shelled edamame, sautéing for 5 minutes until the vegetables are tender-crisp.
Pour the prepared sauce over the tofu and vegetables, tossing constantly for 1-2 minutes until the sauce thickens and becomes glossy.
Remove from heat and garnish with sesame seeds before serving hot.