Preheat your oven to 400°F (200°C) and line a large sheet pan with parchment paper for easy cleanup.
Pat the chicken breast dry with paper towels to ensure a golden sear, then place it on one side of the prepared pan.
Trim the woody ends off the asparagus spears and place them on the other side of the sheet pan.
In a small bowl, whisk together the olive oil, minced garlic, the zest and juice from the lemon, oregano, garlic powder, salt, and pepper.
Drizzle the herb mixture over both the chicken and the asparagus, using your hands or a brush to coat everything evenly.
Roast in the oven for 20 to 25 minutes, or until the chicken reaches an internal temperature of 165°F and the asparagus is tender.
Let the chicken rest for 5 minutes before slicing to keep it juicy, then serve immediately with the roasted asparagus.