Preheat your oven to 400°F and line a large baking sheet with parchment paper for easy cleanup.
Trim the woody ends off the asparagus and toss the spears on the baking sheet with olive oil, half of the sea salt, and half of the black pepper.
Roast the asparagus for 10-12 minutes until they are tender and slightly charred at the tips.
While the vegetables roast, pat the salmon fillet completely dry with a paper towel and season both sides with the remaining sea salt, black pepper, and garlic powder.
Heat the ghee in a cast-iron or stainless steel skillet over medium-high heat until it begins to shimmer.
Place the salmon in the skillet skin-side up and sear undisturbed for 4-5 minutes until a beautiful golden crust forms.
Carefully flip the salmon and continue cooking for another 3-4 minutes until the fish is opaque and flakes easily with a fork.
Plate the salmon immediately alongside the roasted asparagus and serve with a fresh lemon wedge to brighten the flavors.