Preheat your oven to 425°F and line a large rimmed baking sheet with parchment paper for easy cleanup.
Cut the chicken breast into one-inch cubes and break the cauliflower into bite-sized florets.
In a large mixing bowl, whisk together the melted ghee and buffalo hot sauce until well combined.
Add the chicken and cauliflower to the bowl, tossing thoroughly to ensure every piece is coated in the spicy glaze.
Spread the mixture onto the prepared baking sheet in a single layer, ensuring pieces aren't overcrowded to allow for proper roasting.
Bake for 20 to 25 minutes, flipping halfway through, until the chicken is cooked through and the cauliflower edges are slightly charred.
While the bites roast, whisk together the Greek yogurt, garlic powder, onion powder, dried dill, sea salt, black pepper, and lemon juice in a small bowl to create the ranch dip.
Serve the warm buffalo bites immediately with the chilled, creamy ranch dip on the side.