Preheat your oven to 400°F and line a large baking sheet with parchment paper for easy cleanup.
In a large mixing bowl, combine the ground beef, egg, nutritional yeast, sea salt, black pepper, garlic powder, onion powder, and dried oregano.
Gently mix the ingredients by hand until just combined, ensuring you do not overwork the meat to maintain a light and tender texture.
Roll the mixture into 12 even-sized meatballs and arrange them on the prepared baking sheet with space between each.
Bake the meatballs for 15 to 18 minutes, or until they are golden brown and reach an internal temperature of 160°F.
While the meatballs are in the oven, pour the marinara sauce into a large skillet and warm it over medium-low heat.
In a separate non-stick pan, heat the olive oil and lightly sauté the zucchini noodles for 2 to 3 minutes until they are tender but still have a slight bite.
Carefully transfer the baked meatballs into the skillet with the warm marinara sauce, tossing gently to coat them thoroughly.
Plate the zucchini noodles and top with the saucy meatballs, serving immediately while hot.