In a glass mixing bowl, combine the ground turkey, buffalo sauce, garlic powder, sea salt, and black pepper.
Gently fold in half of the blue cheese crumbles, ensuring they are distributed without over-mixing the meat.
Form the mixture into one large, uniform patty about 1-inch thick.
Heat a cast-iron skillet over medium-high heat and add the avocado oil, swirling to coat the pan.
Place the patty in the hot skillet and sear for 5-6 minutes until a deep golden crust forms.
Flip the burger and cook for another 5 minutes, or until the internal temperature reaches 165°F.
Prepare the lettuce wraps by washing and drying two large butter lettuce leaves.
Slice the red onion into thin rings and the avocado into thick wedges.
Place the cooked burger onto the lettuce leaves and top with the remaining blue cheese, red onion, and avocado.